2-Iodoaniline (2-Iodophenylamine) is an aniline derivative, and has potential hepatotoxic and nephrotoxic activity[1].
2-Iodoaniline (1.0 mM/kg, 1.25 mM/kg for 2.5 mL; i.p.; single dose) exhibits hepatotoxic and nephrotoxic potential in Male Fischer 344 rats[1].
| Animal Model: | Male Fischer 344 rats (185-260 g)[1] |
| Dosage: | 1.0 mM/kg, 1.25 mM/kg for 2.5 mL |
| Administration: | Intraperitoneal injection; single dose; monitored renal and hepatic function 24 h after treatment |
| Result: | Induced oliguria, diminished kidney weight, tubular casts and decreased renal cortical slice accumulation of organic anions. Elevated plasma ALT/GPT activity and altered morphology in the centrilobular region. |
[1]. Valentovic MA, et al. Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats. Toxicology. 1992 Nov 1;75(2):121-31.