2-Aminotetralin is a neuromodulatory agent.1,2,3 It inhibits serotonin (5-HT) and norepinephrine reuptake in rat brain when administered at a dose of 39.4 mg/kg.1 2-Aminotetralin induces hypothermia in rats when administered by intracisternal or intraperitoneal injection, but implantation of 2-aminotetralin crystals in the medial preoptic area of the hypothalamus induces hyperthermia in rats.2 It substitutes for (+)-amphetamine in rats in a two-lever drug discrimination test in a dose-dependent manner.3
1.Bruinvels, J.Evidence for inhibition of the reuptake of 5-hydroxytryptamine and noradrenaline by tetrahydronaphthylamine in rat brainBr. J. Pharmacol.42(2)281-286(1971) 2.Bruinvels, J., and Kemper, G.C.Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the ratBr. J. Pharmacol.43(1)1-9(1971) 3.Oberlender, R., and Nichols, D.E.Structural variation and (+)-amphetamine-like discriminative stimulus propertiesPharmacol. Biochem. Behav.38(3)581-586(1991)