2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis[1][2].
2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers[2].
2,4,6-Triiodophenol (5 μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos[2].
2,4,6-Triiodophenol (5-50 μM; 100 h) induces oxidative stress in mouse pre-implantation embryos[2].
Apoptosis Analysis[2]
| Cell Line: | Mouse blastocyst cells |
| Concentration: | 5 μM |
| Incubation Time: | 85 hours |
| Result: | Showed signals of activated Caspase-3/7. |
Immunofluorescence[2]
| Cell Line: | Mouse blastocyst cells |
| Concentration: | 5-50 μM |
| Incubation Time: | 100 hours |
| Result: | Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol. |
[1]. Liu S, et al. 2,4,6-triiodophenol exhibits embryotoxicity to pre-implantation mouse embryos in an in vitro exposure model. Ecotoxicol Environ Saf. 2022 Aug;241:113745.
[2]. TrocÓniz IF, et al. Dealing with time-dependent pharmacokinetics during the early clinical development of a new leukotriene B4 synthesis inhibitor. Pharm Res. 2006 Jul;23(7):1533-42.