2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt)

2'-Deoxy-3'-O-(N'-metlanthraniloyl)guanosine-5'-O-triphosphate (2’-deoxy-3’-MANT-GTP) is a fluorescent derivative of dGTP .^1,2,3 It selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (K_is = 260, 1,200, 420, and 470 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; K_i = 220 nM), and B. anthracis edema factor AC toxin (K_i = 630 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (K_is = 43 and 14 µM, respectively).¹ 2’-deoxy-3’-MANT-GTP has been used to study the activity of various GTPases, including elongation factor Tu (EF-Tu) and H-Ras p21.^2,3