2,3-Oxidosqualene is an intermediate in the biosynthesis of sterols such as lanosterol , cycloartenol, and cholesterol .1,2 It is also an intermediate in the biosynthesis of the triterpenoid β-amyrin .3
1.Nes, W.D.Biosynthesis of cholesterol and other sterolsChem. Rev.111(10)6423-6451(2011) 2.Willett, J.D., Sharpless, K.B., Lord, K.E., et al.Squalene-2,3-oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterolJ. Biol. Chem.242(18)4182-4191(1967) 3.Kajikawa, M., Yamato, K.T., Fukuzawa, H., et al.Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli LPhytochemistry66(15)1759-1766(2005)