2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is an antimicrobial agent.1 It is active against the Gram-negative bacteria E. coli, P. aeruginosa, and S. marcescens (MICs = 64, 100, and 70 μg/ml, respectively), the Gram-positive bacteria S. aureus, M. luteus, and B. cereus (MICs = 130, 100, and 50 μg/ml, respectively), and the fungi C. albicans, G. candidum, T. rubrum, F. oxysporum, A. flavus, and S. brevicaulis (MICs = 69-120 μg/ml). 2-(1-(Thiophen-2-yl)ethylidene)hydrazinecarbothioamide is also a precursor in the synthesis of other antimicrobial agents, as well as compounds with anticancer activity.1,2
1.Youssef, M.S.K., and Abeed, A.A.O.Synthesis and antimicrobial activity of some novel 2-thienyl substituted heterocyclesHeterocycl. Commun.20(1)25-31(2014) 2.Gomha, S.M., Edrees, M.M., and Altalbawy, F.M.A.Synthesis and characterization of some new bis-pyrazolyl-thiazoles incorporating the thiophene moiety as potent anti-tumor agentsInt. J. Mol. Sci.17(9)1499(2016)