(±)-Norepinephrine-d6 (hydrochloride)

(±)-Norepinephrine-d₆ is intended for use as an internal standard for the quantification of norepinephrine by GC- or LC-MS. (±)-Norepinephrine is a racemic mixture of the endogenous neurotransmitter (–)-norepinephrine and (+)-norepinephrine. It induces cAMP accumulation in rat cerebral cortical membranes when used at concentrations ranging from 1 to 100 µM.¹ (±)-Norepinephrine induces contraction of bovine anterior cerebral, middle cerebral, and internal carotid arterial strips (EC50s = 0.91, 0.92, and 0.87 µM, respectively) but induces relaxation of bovine posterior cerebral arterial strips (EC₅₀ = 0.95 µM).² Formulations containing (±)-norepinephrine have been used for the restoration of blood pressure in acute potensive states.