(±)11(12)-DiHET-d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)11(12)-DiHET by GC- or LC-mass spectrometry. Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)11(12)-DiHET relaxes U-46619 -contracted artery rings with approximately 70% of the magnitude of (±)11(12)-EET .2
1.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982)
2.Fang, X., Kaduce, T.L., Weintraub, N.L., et al.Functional implications of a newly characterized pathway of 11,12-epoxyeicosatrienoic acid metabolism in arterial smooth muscleCirculation Research79784-793(1996)
