(±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid is an oxylipin. It is produced from α-linolenic acid by the gut bacteria L. plantarum.1 (±)-10-hydroxy-12(Z),15(Z)-Octadecadienoic acid prevents increases in mRNA expression of the gene encoding SREBP-1c by the liver X receptor (LXR) agonist T0901317 in HepG2 cells. It reduces LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages when used at a concentration of 10 µM.2
1.Nanthirudjanar, T., Furumoto, H., Zheng, J., et al.Gut microbial fatty acid metabolites reduce triacylglycerol levels in hepatocytesLipids50(11)1093-1102(2015) 2.Yang, H.-E., Li, Y., Nishimura, A., et al.Synthesized enone fatty acids resembling metabolites from gut microbiota suppress macrophage-mediated inflammation in adipocytesMol. Nutr. Food Res.61(10)(2017)