GlpBio

15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α

目录号: GC49036纯度: >98.00%同义词: 15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α, 15-(6-nitroxyhexanoyl)-Bimatoprost, NCX 470
A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
Cas No.: 1194396-71-8
规格价格库存数量操作
1 mg¥1,494.00现货
1
5 mg¥5,929.00现货
1
10 mg¥10,349.00现货
1
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产品描述 Description

15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α (15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α .1 It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α (0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.

1.Impagnatiello, F., Toris, C.B., Batugo, M., et al.Intraocular pressure-lowering activity of NCX 470, a novel nitric oxide-donating bimatoprost in preclinical modelsInvest. Ophthalmol. Vis. Sci.56(11)6558-6564(2015)

产品文档 Product Documents

Purity:>98.00%Appearance:A solution in ethanol

化学性质Chemical Properties

CAS 号
1194396-71-8
同义词
15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α, 15-(6-nitroxyhexanoyl)-Bimatoprost, NCX 470
SMILES
O[C@@H]1C[C@H](O)[C@H](C/C=C\CCCC(NCC)=O)[C@H]1/C=C/[C@H](CCC2=CC=CC=C2)OC(CCCCCO[N+]([O-])=O)=O
分子式
C31H46N2O8
分子量
574.7 g/mol
溶解性
DMSO: 10 mg/ml,Ethanol: 10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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