14R(15S)-EET is an oxylipin and a metabolite of arachidonic acid .[1] It is formed via oxidation of arachidonic acid by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. 14R(15S)-EET (10 µM) induces relaxation of precontracted isolated bovine coronary arteries.[2]
References:
[1].Daikh, B.E., Lasker, J.M., Raucy, J.L., et al.Regio- and stereoselective epoxidation of arachidonic acid by human cytochromes P450 2C8 and 2C91J. Pharmacol. Exp. Ther.271(3)1427-1433(1994).
[2].Falck, J.R., Krishna, U.M., Reddy, Y.K., et al.Comparison of vasodilatory properties of 14,15-EET analogs: Structural requirements for dilationAm. J. Physiol. Heart Circ. Physiol.284(1)337-349(2003).
















