119-23 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo.1 LNPs containing 119-23 and encapsulating an mRNA reporter show greater intramuscular transfection efficacy compared to LNPs containing the ionizable cationic lipids SM-102 or DLin-MC3-DMA in mice. 119-23-containing LNPs accumulate in mouse hepatic and splenic immune cells to a greater extent than SM-102-containing LNPs. LNPs containing 119-23 and encapsulating mRNA encoding human erythropoietin (hEPO) increase serum hEPO levels in mice.
References:
[1]. Li, B., Raji, I.O., Gordon, A.G.R., et al.Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistryNat. Mater.23(7)1002-1008(2024).