10-hydroxy Decanoic acid is a hydroxy fatty acid and a major component of worker bee mandibular blend pheromones that has been found in royal jelly.1,2 It reduces LPS-induced nitric oxide production in RAW 264.7 cells when used at a concentration of 5 mM.2
1.Plettner, E., Sutherland, G.R., Slessor, K.N., et al.Why not be a queen? Regioselectivity in mandibular secretions of honeybee castesJ. Chem. Ecol.21(7)1017-1029(1995) 2.Chen, Y.-F., Wang, K., Zhang, Y.-Z., et al.In vitro anti-inflammatory effects of three fatty acids from royal jellyMediators Inflamm.3583684(2016)