1-Octen-3-ol is a volatile organic compound (VOC) that has been found in fungi and plants.1 It has also been found in oxen breath and human sweat and is an attractant for Ochlerotatus, Psorophora, Anopheles, and Coquillettidia mosquitoes but a repellant for Culex mosquitoes.1,2 1-Octen-3-ol (3 and 10 ppm) inhibits dopamine uptake in HEK cells expressing the human dopamine transporter (HEK-DAT cells).3 It induces dopaminergic neuron loss and locomotor deficits in, as well as reduces survival of, D. melanogaster when administered via inhalation at a dose of 0.5 ppm.
1.Xu, P., Zhu, F., Buss, G.K., et al.1-Octen-3-ol ? the attractant that repelsF1000Res.4156(2015) 2.Kline, D.L., Allan, S.A., Bernier, U.R., et al.Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.AMed. Vet. Entomol.21(4)323-331(2007) 3.Inamdar, A.A., Hossain, M.M., Bernstein, A.I., et al.Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegenerationProc. Natl. Acad. Sci. USA110(48)19561-19566(2013)