1-Linoleoyl Lysophosphatidic Acid (sodium salt)

1-Linoleoyl lysophosphatidic acid (1-linoleoyl LPA) is an agonist of the LPA₂ receptor and a glycerophospholipid containing linoleic acid at the sn-1 position.¹ It is the most abundant LPA in mouse and human plasma.^2,3 1-Linoleoyl LPA selectively increases intracellular calcium levels in LPA₂ receptor-expressing Sf9 cells (EC₅₀ = ~10 nM) over LPA₁ and LPA₃ receptor-expressing Sf9 cells (EC₅₀s = ~200 and ~80 nM, respectively).¹ Serum levels of 1-linoleoyl LPA are increased in mice bearing NCTC clone 2472 tumors.⁴ Plasma 1-linoleoyl LPA levels are decreased in patients with primary progressive, but not relapsing-remitting, multiple sclerosis and are negatively correlated with neurological deficit severity.⁵