1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (18:1 PA; DOPA) is an anionic lipid that can be used to prepare liposomes, micelles, and artificial membranes[1]. 1,2-Dioleoyl-sn-glycero-3-phosphate is a phospholipid containing the long-chain fatty acid oleic acid inserted at the sn-1 and sn-2 positions[2]. 1,2-Dioleoyl-sn-glycero-3-phosphate is one of the major phosphatidic acid (PA) species in most tissues and cells[3]. 1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt can be used to prepare Zol-Ca composite nanoparticle formulations to improve the delivery and enhance the distribution of Zol in mouse tumor models[4]. Calcium phosphate (CaP)-coated DOPA liposomes have good biomembrane staining ability[5].
References:
[1] Siepi E. Mechanism of amphoteric liposomes & application for siRNA delivery[D]. Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Diss., 2010, 2010.
[2] Rouet‐Mayer M A, Valentova O, Simond‐Côte E, et al. Critical analysis of phospholipid hydrolyzing activities in ripening tomato fruits. Study by spectrofluorimetry and high‐performance liquid chromatography[J]. Lipids, 1995, 30(8): 739-746.
[3] Hoshino F, Sakane F. Polyunsaturated fatty acid-containing phosphatidic acids selectively interact with L-lactate dehydrogenase A and induce its secondary structural change and inactivation[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(10): 158768.
[4] Li X, Naguib Y W, Valdes S, et al. Reverse Microemulsion-Based Synthesis of (Bis) phosphonate–Metal Materials with Controllable Physical Properties: An Example Using Zoledronic Acid–Calcium Complexes[J]. ACS applied materials & interfaces, 2017, 9(16): 14478-14489.
[5] Berti I R, Dell’Arciprete M L, Dittler M L, et al. Delivery of fluorophores by calcium phosphate-coated nanoliposomes and interaction with Staphylococcus aureus biofilms[J]. Colloids and Surfaces B: Biointerfaces, 2016, 142: 214-222.
1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt（18:1 PA；DOPA）是一种阴离子脂质，可用于制备脂质体、胶束和人工膜[1]。1,2-Dioleoyl-sn-glycero-3-phosphate是一种磷脂，含有插入sn-1和sn-2位置的长链脂肪酸油酸[2]。1,2-Dioleoyl-sn-glycero-3-phosphate是大多数组织和细胞中的主要磷脂酸（PA）种类之一[3]。1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt可用于制备Zol-Ca复合纳米颗粒制剂，以改善Zol在小鼠肿瘤模型中的递送并增强其分布[4]。磷酸钙（CaP）包被的DOPA脂质体，具有良好的生物膜染色能力[5]。