GlpBio

1,2-Dimyristoyl-sn-glycero-3-PC

目录号: GC41803纯度: >99.00%同义词: 二肉豆蔻酰磷脂酰胆碱（DMPC）,DMPC; Dimyristoyl phosphatidylcholine
1,2-Dimyristoyl-sn-glycero-3-PC是一种合成磷脂。
1,2-Dimyristoyl-sn-glycero-3-PC
Cas No.: 18194-24-6
规格价格库存数量操作
250mg¥590.00现货
1
500mg¥937.00现货
1
1g¥1,421.00现货
1
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产品描述 Description

1,2-Dimyristoyl-sn-glycero-3-PC is a synthetic phospholipid[1]. 1,2-Dimyristoyl-sn-glycero-3-PC is usually used to construct liposomes for the study of lipid monolayer and bilayer structures and drug delivery systems[2][3]. 1,2-Dimyristoyl-sn-glycero-3-PC can also be used in metabolism-related research[4].

In vitro, 1,2-Dimyristoyl-sn-glycero-3-PC (200μg/mL; 24h) significantly enhanced PVP-SPIONs uptake in PC-12 cells[5]. 1,2-Dimyristoyl-sn-glycero-3-PC (0.08-250μM; 72h) increases Carmofur stability and antiproliferative effect in C6 glioma cells[6].

In vivo, 1,2-Dimyristoyl-sn-glycero-3-PC (2-2.5mg/day/mouse in drinking water; 8 weeks) significantly reduced aortic sinus lesion area and en face whole aorta lesion area in 6-month-old male apoE-null mice[7].

References:
[1] Fountain MW, Ganjam VK, Schultz RD. Liposome carrier vehicle for triiodothryonine. Clin Exp Pharmacol Physiol. 1982;9(1):101-105.
[2] Budziak I, Arczewska M, Sachadyn-Król M, et al. Effect of polyols on the DMPC lipid monolayers and bilayers. Biochim Biophys Acta Biomembr. 2018;1860(11):2166-2174.
[3] Marcos X, Sixto-López Y, Pérez-Casas S, Correa-Basurto J. Computational study of DMPC liposomes loaded with the N-(2-Hydroxyphenyl)-2-propylpentanamide (HO-AAVPA) and determination of its antiproliferative activity in vitro in NIH-3T3 cells. J Biomol Struct Dyn. 2022;40(21):11448-11459.
[4] Du K, Sun L, Luo Z, et al. Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity. Metabolism. 2022;131:155181.
[5] Han D, Zhang B, Dong J, et al. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine promotes the adhesion of nanoparticles to bio-membranes and transport in rat brain. RSC Adv. 2021;11(56):35455-35462.
[6] Domracheva I, Muhamadejev R, Petrova M, et al. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect. Toxicol Rep. 2015;2:377-383.
[7] Navab M, Hama S, Hough G, Fogelman AM. Oral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis in apolipoprotein E-null mice. Circulation. 2003;108(14):1735-1739.

1,2-Dimyristoyl-sn-glycero-3-PC是一种合成磷脂[1]。1,2-Dimyristoyl-sn-glycero-3-PC通常用于构建脂质体以研究脂质单层和双层结构以及药物递送系统[2][3]。1,2-Dimyristoyl-sn-glycero-3-PC还可用于代谢相关研究[4]。

在体外实验中，1,2-Dimyristoyl-sn-glycero-3-PC（200μg/mL；24小时）显著增强了PC-12细胞对PVP-SPIONs的摄取[5]。1,2-Dimyristoyl-sn-glycero-3-PC (0.08-250μM；72小时）在C6胶质瘤细胞中提高卡莫福尔的稳定性，并增强抗增殖效果[6]。

在体内实验中，1,2-Dimyristoyl-sn-glycero-3-PC（2-2.5mg/day/mouse；通过饮用水给药；持续8周）显著减少了6个月大雄性apoE基因敲除小鼠的主动脉窦病变面积和全主动脉病变面积[7]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

C6 glioma cells

Preparation Method

1,2-Dimyristoyl-sn-glycero-3-PC vesicles were prepared as follows: Carmofur (26mg, 0.1mmol) and 1,2-Dimyristoyl-sn-glycero-3-PC (0.334g, 0.5mmol) were dissolved in 25ml of chloroform and evaporated on rotatory evaporator under reduced pressure with slow rotation without any heating. Then additional portion of chloroform was added and the procedure was repeated for 5 times. C6 glioma cells were grown in standard medium Dulbecco’s modified Eagle’s medium (DMEM) supplemented with 10% fetal bovine serum. About 1-2×104cells/well were placed in 96-well plates immediately after 1,2-Dimyristoyl-sn-glycero-3-PC vesicles (250, 50, 10, 2, 0.4 and 0.08μM) were added to the wells. The plates were incubated for 72h, at 37℃, 5% CO2. The number of surviving cells was determined using MTT assay. The control cells were cultured on separate plate and an appropriate volume of control buffer was added to control cells. Each assay was conducted in triplicate.

Reaction Conditions

0.08-250μM; 72h

Applications

1,2-Dimyristoyl-sn-glycero-3-PC increases Carmofur stability and antiproliferative effect in C6 glioma cells.
Animal experiment [2]:

Animal models

Male and female apoE-null mice

Preparation Method

Male and female apoE-null mice were maintained on a chow diet. The 1,2-Dimyristoyl-sn-glycero-3-PC, obtained in the form of a fine powder, readily resulted in a uniform suspension when mixed in water for 1mg/mL. The suspension was added to 50-mL graduated polypropylene tubes fitted with standard rubber stoppers and stainless steel tubes of a type used routinely in mouse water bottles. 1mg/mL 1,2-Dimyristoyl-sn-glycero-3-PC in the drinking water was given to mice for 8 weeks. The tubes were observed daily, and the lipids were found by inspection to remain in suspension. The contents of the tubes were changed every other day. The mice drank 2 to 2.5mL/d per mouse, and there was no significant difference in the amount of suspension consumed between the groups. Aortic lesions were scored by histopathology analysis.

Dosage form

2-2.5mg/day/mouse in drinking water; 8 weeks

Applications

1,2-Dimyristoyl-sn-glycero-3-PC significantly reduced aortic sinus lesion area and en face whole aorta lesion area in 6-month-old male apoE-null mice.

References:
[1] Domracheva I, Muhamadejev R, Petrova M, et al. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect. Toxicol Rep. 2015;2:377-383.
[2] Navab M, Hama S, Hough G, Fogelman AM. Oral synthetic phospholipid (DMPC) raises high-density lipoprotein cholesterol levels, improves high-density lipoprotein function, and markedly reduces atherosclerosis in apolipoprotein E-null mice. Circulation. 2003;108(14):1735-1739.

产品文档 Product Documents

Purity:>99.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
18194-24-6
同义词
二肉豆蔻酰磷脂酰胆碱（DMPC）,DMPC; Dimyristoyl phosphatidylcholine
SMILES
O=C(CCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O
分子式
C36H72NO8P
分子量
677.9 g/mol
溶解性
Ethanol: 25 mg/ml
保存条件
Store at 2-8°C, protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol