1,2,3-Triheptanoyl-rac-glycerol is a triacylglycerol that contains heptanoic acid at the sn-1, sn-2, and sn-3 positions. It increases levels of propionyl carnitine , pentanoyl carnitine , and heptanoyl carnitine in mouse blood when administered as 35% of calories in the diet.1 1,2,3-Triheptanoyl-rac-glycerol (35% of calories in the diet) also delays the development of corneal kindling-induced seizures in mice and increases the pentylenetetrazole tonic extension threshold during the chronically epileptic stage in a mouse model of pilocarpine-induced status epilepticus.
|1. Willis, S., Stoll, J., Sweetman, L., et al. Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models. Neurobiol. Dis. 40(3), 565-572 (2010).