0990CL is a specific heterotrimeric Gαi subunit inhibitor by direct interaction with Gαi[1]. 0990CL partially restored cAMP levels by inhibiting Gαi and blocking α2AR-mediated cAMP regulation[2].
References:
[1] Ayoub M A. Small molecules targeting heterotrimeric G proteins[J]. European journal of pharmacology, 2018, 826: 169-178.
[2] Appleton K M, Bigham K J, Lindsey C C, et al. Development of inhibitors of heterotrimeric Gαi subunits[J]. Bioorganic & medicinal chemistry, 2014, 22(13): 3423-3434.
0990CL是一种特异性异源三聚体Gαi亚基抑制剂，通过与Gαi直接相互作用实现[1]。0990CL通过抑制Gαi并阻断α2AR介导的cAMP调节，部分恢复了cAMP水平[2]。